Genetic changes arising in human pluripotent stem cells (hPSC) upon culture may bestow unwanted or detrimental phenotypes to cells, thus potentially impacting on the applications of hPSCs for clinical use and basic research. In the 20 years since the first report of culture‐acquired genetic aberrations in hPSCs, a characteristic spectrum of recurrent aberrations has emerged. The preponderance of such aberrations implies that they provide a selective growth advantage to hPSCs upon expansion. However, understanding the consequences of culture‐acquired variants for specific (...) applications in cell therapy or research has been more elusive. The rapid progress of hPSC‐based therapies to clinics is galvanizing the field to address this uncertainty and provide definitive ways both for risk assessment of variants and reducing their prevalence in culture. Here, we aim to provide a timely update on almost 20 years of research on this fascinating, but a still unresolved and concerning, phenomenon. (shrink)

While we are commonly told that the distinctive method of mathematics is rigorous proof, and that the special topic of mathematics is abstract structure, there has been no agreement among mathematicians, logicians, or philosophers as to just what either of these assertions means. John P. Burgess clarifies the nature of mathematical rigor and of mathematical structure, and above all of the relation between the two, taking into account some of the latest developments in mathematics, including the rise of experimental (...) mathematics on the one hand and computerized formal proofs on the other hand. Along the way, a great many historical developments in mathematics, philosophy, and logic are surveyed. Yet very little in the way of background knowledge on the part of the reader is presupposed. (shrink)

Darwinism, Democracy, and Race examines the development and defence of an argument that arose at the boundary between anthropology and evolutionary biology in twentieth-century America. In its fully articulated form, this argument simultaneously discredited scientific racism and defended free human agency in Darwinian terms. The volume is timely because it gives readers a key to assessing contemporary debates about the biology of race. By working across disciplinary lines, the book's focal figures--the anthropologist Franz Boas, the cultural anthropologist Alfred Kroeber, the (...) geneticist Theodosius Dobzhansky, and the physical anthropologist Sherwood Washburn--found increasingly persuasive ways of cutting between genetic determinist and social constructionist views of race by grounding Boas's racially egalitarian, culturally relativistic, and democratically pluralistic ethic in a distinctive version of the genetic theory of natural selection. Collaborators in making and defending this argument included Ashley Montagu, Stephen Jay Gould, and Richard Lewontin. Darwinism, Democracy, and Race will appeal to advanced undergraduates, graduate students, and academics interested in subjects including Philosophy, Critical Race Theory, Sociology of Race, History of Biology and Anthropology, and Rhetoric of Science. (shrink)

David Hume's A Treatise of Human Nature presents the most important account of skepticism in the history of modern philosophy. In this lucid and thorough introduction to the work, John P. Wright examines the development of Hume's ideas in the Treatise, their relation to eighteenth-century theories of the imagination and passions, and the reception they received when Hume published the Treatise. He explains Hume's arguments concerning the inability of reason to establish the basic beliefs which underlie science and morals, (...) as well as his arguments showing why we are nevertheless psychologically compelled to accept such beliefs. The book will be a valuable guide for those seeking to understand the nature of modern skepticism and its connection with the founding of the human sciences during the Enlightenment. (shrink)

A philosopher once wrote the following words:If I examine the PTOLOMAIC and COPERNICAN systems, I endeavour only, by my enquiries, to know the real situation of the planets; that is, in other words, I endeavour to give them, in my conception, the same relations, that they bear towards each other in the heavens. To this operation of the mind, therefore, there seems to be always a real, though often an unknown standard, in the nature of things; nor is truth or (...) falsehood variable by the various apprehensions of mankind. Though all human race should for ever conclude, that the sun moves, and the earth remains at rest, the sun stirs not an inch from his place for all these reasonings; and such conclusions are eternally false and erroneous. (shrink)

What role do moment‐to‐moment comprehension processes play in visual attentional selection in picture stories? The current work uniquely tested the role of bridging inference generation processes on eye movements while participants viewed picture stories. Specific components of the Scene Perception and Event Comprehension Theory (SPECT) were tested. Bridging inference generation was induced by manipulating the presence of highly inferable actions embedded in picture stories. When inferable actions are missing, participants have increased viewing times for the immediately following critical image (Magliano, (...) Larson, Higgs, & Loschky, ). This study used eye‐tracking to test competing hypotheses about the increased viewing time: (a) Computational Load: inference generation processes increase overall computational load, producing longer fixation durations; (b) Visual Search: inference generation processes guide eye‐movements to pick up inference‐relevant information, producing more fixations. Participants had similar fixation durations, but they made more fixations while generating inferences, with that process starting from the fifth fixation. A follow‐up hypothesis predicted that when generating inferences, participants fixate scene regions important for generating the inference. A separate group of participants rated the inferential‐relevance of regions in the critical images, and results showed that these inferentially relevant regions predicted differences in other viewers’ eye movements. Thus, viewers’ event models in working memory affect visual attentional selection while viewing visual narratives. (shrink)

With gratitude for our commentators’ thoughtful and generous engagement with Recognizing Wrongs, we offer in this reply a thumbnail summary of their comments and responses to some of their most important questions and criticisms. In the spirit of friendly amendment, Tom Dougherty and Johann Frick suggest that a more satisfactory version of our theory would cast tort actions as a means of enforcing wrongdoers’ moral duties of repair. We provide both legal and moral reasons for declining their invitation. Rebecca Stone (...) draws a particular link between civil recourse in private law theory and the right of self-defense as recognized in criminal law and moral theory. While we share Stone’s basic inclination, we argue for a different version of the link than the one that she draws. Veronica Rodriguez-Blanco provides a critique of our model of negligence law based on action theory. In response, we explain – in a way that we hope sheds light on debates over moral luck – how it is possible for the law to define negligence such that its commission depends simultaneously on the character of the defendant’s conduct and on the consequences that result from it. Though generally sympathetic to our approach, Stephen Smith faults us for failing satisfactorily to explain important remedial dimensions of tort law. Stubbornly, we insist that we can account for these, and indeed can do so on more satisfactory terms than corrective justice theorists. Finally, Erin Kelly challenges us to consider how our work might inform the analysis of two pressing issues of racial justice: overcriminalization and reparation payments. While we question whether our work to date has as much to offer on these matters as she suggests, we also maintain that the core principle of civil recourse theory – where there is a right there is a remedy – provides grounds for critiquing modern law’s failure to provide adequate accountability when police officers use excessive force against persons of color. (shrink)

We propose a multi-step evaluation schema designed to help procurement agencies and others to examine the ethical dimensions of autonomous systems to be applied in the security sector, including autonomous weapons systems.

Quine correctly argues that Carnap's distinction between internal and external questions rests on a distinction between analytic and synthetic, which Quine rejects. I argue that Quine needs something like Carnap's distinction to enable him to explain the obviousness of elementary mathematics, while at the same time continuing to maintain as he does that the ultimate ground for holding mathematics to be a body of truths lies in the contribution that mathematics makes to our overall scientific theory of the world. Quine's (...) arguments against the analytic/synthetic distinction, even if fully accepted, still leave room for a notion of pragmatic analyticity sufficient for the indicated purpose. (shrink)

Critics of organ donation after circulatory death (DCD) argue that, even if donors are past the point of autoresuscitation, they have not satisfied the “irreversibility” requirement in the circulatory and respiratory criteria for determining death, since their circulation and respiration could be artificially restored. Thus, removing their vital organs violates the “dead-donor” rule. I defend DCD donation against this criticism. I argue that practical medical-ethical considerations, including respect for do-not-resuscitate orders, support interpreting “irreversibility” to mean permanent cessation of circulation and (...) respiration. Assuming a consciousness-related formulation of human death, I then argue that the loss of circulation and respiration is significant, because it leads to the permanent loss of consciousness and thus to the death of the human person. The DNR request by an organ donor should thus be interpreted to mean “do not restore to consciousness.” Finally, I respond to an objection that if “irreversibility” has a medical-ethical meaning, it would entail the absurd possibility that one of two individuals in the same physical state could be alive and the other dead—an implication that some think is inconsistent with understanding death as an objective biological state of the organism. I argue that advances in medical technology have created phenomena that challenge the assumption that human death can be understood in strictly biological terms. I argue that ethical and ontological considerations about our nature bear on the definition and determination of death and thus on the permissibility of DCD. (shrink)

Cognitive Science, Volume 46, Issue 5, May 2022.

The increasingly pervasive practice of veiling among Muslim women has stimulated a great deal of scholarly investigation and debate. This study brings empirical evidence to bear on current debates about the meaning of the veil in Islam. This article first examines the conflicting meanings of the veil among Muslim religious elites and Islamic feminists. Although the dominant gender discourse among Muslim elites strongly favors this cultural practice, an antiveiling discourse promulgated by Islamic feminists has gained ground within recent years. This (...) study then examines how these discursive disputes affect gender identity negotiation among veiled and unveiled Muslim women living in Austin, Texas. Interviews with these women highlight how their gender identities reproduce and reformulate existing Muslim gender discourses. Special attention is paid to the subjective disparities and points of congruence between both groups of respondents. This study concludes by suggesting avenues for future research on the intersection of gender, religion, and cultural difference. (shrink)

Hintikka and Sandu have recently claimed that Frege's notion of function was substantially narrower than that prevailing in real analysis today. In the present note, their textual evidence for this claim is examined in the light of relevant historical and biographical background and judged insufficient.

The great logician Gottlob Frege attempted to provide a purely logical foundation for mathematics. His system collapsed when Bertrand Russell discovered a contradiction in it. Thereafter, mathematicians and logicians, beginning with Russell himself, turned in other directions to look for a framework for modern abstract mathematics. Over the past couple of decades, however, logicians and philosophers have discovered that much more is salvageable from the rubble of Frege's system than had previously been assumed. A variety of repaired systems have been (...) proposed, each a consistent theory permitting the development of a significant portion of mathematics. This book surveys the assortment of methods put forth for fixing Frege's system, in an attempt to determine just how much of mathematics can be reconstructed in each. John Burgess considers every proposed fix, each with its distinctive philosophical advantages and drawbacks. These systems range from those barely able to reconstruct the rudiments of arithmetic to those that go well beyond the generally accepted axioms of set theory into the speculative realm of large cardinals. For the most part, Burgess finds that attempts to fix Frege do less than advertised to revive his system. This book will be the benchmark against which future analyses of the revival of Frege will be measured. (shrink)

In this paper we introduce a system S5U, formed by adding to the modal system S5 a new connective U, Up being read “probably”. A few theorems are derived in S5U, and the system is provided with a decision procedure. Several decidable extensions of S5U are discussed, and probability logic is related to plurality quantification.

The question, "Which modal logic is the right one for logical necessity?," divides into two questions, one about model-theoretic validity, the other about proof-theoretic demonstrability. The arguments of Halldén and others that the right validity argument is S5, and the right demonstrability logic includes S4, are reviewed, and certain common objections are argued to be fallacious. A new argument, based on work of Supecki and Bryll, is presented for the claim that the right demonstrability logic must be contained in S5, (...) and a more speculative argument for the claim that it does not include S4.2 is also presented. (shrink)

This paper is the third of a multi-part examination of the Babylonian mathematical lunar theories known as Systems A and B. Part I (Britton, AHES 61:83–145, 2007) addressed the development of the empirical elements needed to separate the effects of lunar and solar anomaly on the intervals between syzygies, accomplished in the construction of the System A lunar theory early in the fourth century B.C. Part II (Britton, AHES 63:357–431, 2009) examines the accomplishment of this separation by the construction of (...) a successful theory depicting the variations due to lunar anomaly in System A and its subsequent adaptation in System B. The present paper examines the introduction of the uniform zodiac, necessary for any theory depicting variations depending on the position of syzygy. It addresses three questions: (1) In light of all available evidence, what is the magnitude of the constant term in the expression Δλ* = C − 1.3828°Y, describing the difference between the Babylonian sidereal longitudes and modern tropical longitudes? (2) What considerations governed the placement of the Babylonian sidereal zodiac relative to the fixed stars? (3) When was the uniform zodiac introduced? To the first question it finds C = 3.20° ± 0.1°, scarcely different from Huber’s (Centaurus 5:192–208, 1958) estimate of 3.08°, essentially confirming Huber’s result obtained from much less data. For the second it shows that accommodating the three asterisms comprising Taurus limited the placement of the zodiac to within 3°, while the prominence of half sign multiples among the measured intervals between prominent Normal Stars led irresistibly to the choice adopted. Finally, it finds that the zodiac was introduced between −408 and −397 and probably within a very few years of −400. (shrink)

Scientific authorship has become a contested terrain in contemporary science. Based on a survey of authors across fields, we measure the likelihood of specialist authors : people who only made specialized contributions, such as data, materials, or funding; and “nonauthor collaborators” : those who did significant work on the project but do not appear as authors, across different research contexts, including field, size of the project team, commercial orientation, impact of publication, and organization of the collaboration. We find that guest (...) and ghost authors are common, with about one-third of publications having at least one specialist author and over half having at least one nonauthor collaborator. We see significant cross-field variations in both overall rates and types of specialist authors and nonauthor collaborators. We find there are generally fewer specialist authors among highly cited papers and more graduate student nonauthor collaborators in single location projects. The results suggest authorship practices vary across fields, and by project characteristics, complicating the use of authorship lists as a basis for evaluation. We discuss implications of these findings for interpreting author lists in the context of science policy. (shrink)

In their target article, Nielsen Busch and Mjaaland seek to shift focus away from controversy over whether donors in protocols of controlled donation after circulatory death (cDCD) are dead. Citing...

BackgroundThe Public Health Service Increased Risk designation identified organ donors at increased risk of transmitting hepatitis B, hepatitis C, and human immunodeficiency virus. Despite clear data demonstrating a low absolute risk of disease transmission from these donors, patients are hesitant to consent to receiving organs from these donors. We hypothesize that patients who consent to receiving offers from these donors have decreased time to transplant and decreased waitlist mortality.MethodsWe performed a single-center retrospective review of all-comers waitlisted for liver transplant from (...) 2013 to 2019. The three competing risk events (transplant, death, and removal from transplant list) were analyzed. 1603 patients were included, of which 1244 (77.6%) consented to offers from increased risk donors.ResultsCompared to those who did not consent, those who did had 2.3 times the rate of transplant (SHR 2.29, 95% CI 1.88–2.79, p < 0.0001), with a median time to transplant of 11 months versus 14 months (p < 0.0001), as well as a 44% decrease in the rate of death on the waitlist (SHR 0.56, 95% CI 0.42–0.74, p < 0.0001). All findings remained significant after controlling for the recipient age, race, gender, blood type, and MELD. Of those who did not consent, 63/359 (17.5%) received a transplant, all of which were from standard criteria donors, and of those who did consent, 615/1244 (49.4%) received a transplant, of which 183/615 (29.8%) were from increased risk donors.ConclusionsThe findings of decreased rates of transplantation and increased risk of death on the waiting list by patients who were unwilling to accept risks of viral transmission of 1/300–1/1000 in the worst case scenarios suggests that this consent process may be harmful especially when involving “trigger” words such as HIV. The rigor of the consent process for the use of these organs was recently changed but a broader discussion about informed consent in similar situations is important. (shrink)

: In this commentary we engage with Paul’s Transformative Experience as it relates to decision making. We consider why deciding whether to undergo a transformative experiences can feel so agonizing yet also be so fun, whether people have any preferences to decide over in the first place, and who people even think they are. Keywords: Transformative Experience; Big Decisions; Preference Construction; Theory of Self; Mental Effort Decisioni trasformative e relative insoddisfazioni Riassunto: In questo commento ci concentreremo su come il volume (...) di L.A. Paul Transformative Experience affronta i processi decisionali. Esamineremo perché la decisione se intraprendere un’esperienza trasformativa possa risultare così struggente ed essere altresì divertente; se le persone abbiano in assoluto qualche preferenza nel prendere decisioni definitive e chi le persone persone ritengono di essere. Parole chiave: Esperienza trasformativa; Grandi decisioni; Costruzione delle preferenze; Teoria del sé; Sforzo mentale. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:John P. Anton C. P. CAVAFY'S ARS POETICA ' It is generally recognized that Constantine P. Cavafy (1863-1933) was not born a poet but became one only through persistence and labor, reaching his "first step" sometime after the midpoint of his life. In his effort to assess the quality of his earlier poetic production and sharpen his sensitivity in facing self-criticism, he decided to put in writing his (...) personal thoughts on his work sometime in 1903. The text was written in English in a personal shorthand Cavafy had devised for his own use. It was found among the papers he left to A. Sengopoulos and published for the first time in 1963 by M. Peridis, who also supplied the suitable title Ars Poetica. It falls outside the scope of this essay to discuss the antecedents of this document. Taken as a whole, the text has all the clarity and directness required of a testament designed to serve as a personal guide and handbook. The problems it discusses are limited to the needs of the poet. In this regard, the Ars Poetica has neither the range of topics nor the theoretical scope of, for instance, Aristotle's Poetics. It is quite certain that the ideas that preoccupy Cavafy in the Ars Poetica had been on his mind for a period of years. However, the Ars Poetica is his first prose piece where he gives a systematic treatment to technical and critical issues directly related to the assessment of his work and his role as a poet. In order to project here a clear image of Cavafy's struggle to reach his technical maturity which came after 1910, we need first to discuss the persistent problems he faced during this crucial decade, then to examine the attitudes and values he embodied in certain representative early poems, and finally to relate them to the guiding principles he formulated in his self-addressed poetics of 1903. A number of interrelated problems confronted Cavafy in his late twenties and throughout his thirties. They emerged one by one, to 85 86Philosophy and Literature make more pressing the demand for a consistent solution and a complete recasting of his outlook. Coming to terms with them was extremely difficult. Aside from the emotional and sexual pressures he had to face alone, there was the absence of suitable ideas and conceptual tools to provide him with even the rudiments of an intellectual framework. Whatever he borrowed from Europe and England, or resurrected from his own Hellenic heritage, proved either beyond assimilation or insufficiently digested. The lingering issues fell roughly into four areas. (i) Despite his determination to devote his life to the writing of poetry, the quality of his work was discouraging. He knew this and as a result he often expressed uncertainty about his ability to proceed. Time and again he appeared suffering from a feeling of inadequacy, but nevertheless he sought to engage a reflective mood from which to draw encouragement and hope. (ii) On the theoretical side, he identified with the long tradition which assigned a coveted cultural role to the savant-poet as discloser of truth and spokesman for humanity; this despite the prevailing climate of opinion in his immediate environment which recognized no such high position in his case. Cavafy knew that his standing with the Greek community of Alexandria had gradually dwindled with the loss of family wealth and his lowly employment, and also that his expectations to be respected in his role as a poet and leader in communal affairs were futile. This denial of personal recognition in a society dominated by commerce and finance contributed to his mood of depression. The feeling of being an outcast, despite his associations with the upper social circles of Alexandria, became a constant irritant to his sense of pride. (iii) The course of culture, the destiny of human institutions and the workings of history, became puzzles as he tried to view them through the opaque glass of disillusionment. These were the grand themes actively discussed in the writings of leading European intellectuals, but to the young poet they had a different personal urgency. His vital concern in this connection was not understanding science... (shrink)

This chapter contains section titled: Reception of the Treatise by Francis Hutcheson and Hume's Revisions to Book 3 The Early Reviews of the Treatise and Hume's Response The Principal's Attack in 1745 and Hume's Defence in his Letter from a Gentleman Criticisms of the Treatise after Publication of the Enquiries Thomas Reid's Criticisms of Hume's Philosophy and Hume's Response Hume's Repudiation of the Treatise Conclusion Notes References Further reading.

The most important distinctively American contribution to philosophy is the pragmatist tradition. In this short, lucid, and completely convincing exposition, Professor John P. Murphy begins by exploring the roots of this tradition as found in the work of Peirce, James, and Dewey, demonstrating its power and originality. Historians of philosophy will appreciate the insight Murphy brings to these figures, but the special value of this book lies in his discussion of how the pragmatist spirit has flowered in contemporary philosophy (...) in the work of Quine, Rorty, and Davidson.Throughout, Murphy emphasizes the logic and structure of the views held by these six philosophers and what it is they have in common that makes their work especially “pragmatist.” There is no better introduction to this historical tradition and perhaps no better way into the philosophies of the contemporaries whom Murphy discusses.Interest in pragmatist ideas is undergoing a revival at present, and this book shows us why. It will be of interest to both historians of philosophy and students of contemporary philosophy. (shrink)

This paper challenges the recommendation of 1981 President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research that all jurisdictions in the United States should adopt the Uniform Determination of Death Act, which endorses a whole-brain, rather than a higher-brain, definition of death. I argue that the Commission was wrong to reject the "personhood argument" for the higher-brain definition on the grounds that there is no consensus among philosophers or the general population as to what (...) constitutes "personhood". I claim that philosophers agree that some potential for cognitive function is necessary for personhood and that, when this is absent in cases of anencephaly and persistent vegetative state (PVS), the individual should be considered dead. I further argue that the lack of consensus among the general population is due in large measure to misunderstandings about the medical reality of PVS and beliefs influenced by feelings for a specific individual in PVS. I also examine and reject two tutiorist arguments which have been used to support the Commission's position: that the higher-brain definition would threaten the severely senile and severely retarded, and that there are not currently adequate medical techniques for determining when all higher-brain activities have ceased. Keywords: death, personhood, persistent vegetative state, anencephaly CiteULike Connotea Del.icio.us What's this? (shrink)

This volume reprints a dozen of the author’s papers, most with substantial postscripts, and adds one new one. The bulk of the material is on topics in philosophy of language, but there are also two papers on philosophy of mathematics written after the appearance of the author’s collected papers on that subject, and one on epistemology. As to the substance of Field’s contributions, limitations of space preclude doing much more below than indicating the range of issues addressed, and the general (...) orientation taken towards them. As to the style of his writing, it well exhibits the first of the two virtues, clarity and conciseness, that one looks for in philosophical prose. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume Studies Volume 29, Number 1, April 2003, pp. 125-141 Dr. George Cheyne, Chevalier Ramsay, and Hume's Letter to a Physician JOHN P. WRIGHT The publication of a new intellectual biography of George Cheyne1 provides a "propitious" occasion for "a thoroughly skeptical review"2 of the question which has long exercised Hume scholars, whether Cheyne was the intended recipient of David Hume's fascinating pie-Treatise Letter to a Physician,3 the (...) letter which describes his own hypochondriacal physical and mental symptoms and gives an account of his early philosophical development.4 Hume's nineteenth-century biographer, John Hill Burton, argued that Hume was probably writing to Cheyne,5 while Ernest Mossner claimed to definitively refute that hypothesis in an article entitled "Hume's Epistle to Dr. Arbuthnot," published in 1944.6 Anita Guerrini's intellectual biography does not discuss Cheyne as a possible recipient of Hume's letter, but she does present a well-rounded picture of this interesting eighteenth-century physician from which we can judge his appropriateness as its addressee. In the following discussion I will make use of the biographical material found in this new biography of Cheyne, as well as other sources, to show that Mossner's arguments are less than definitive, and that it would be wrong to dismiss the possibility that the letter was sent to George Cheyne.7 This is a possibility that, for reasons that I will make clear, makes good biographical and philosophical sense. At the same time, it is important to keep a proper suspense of judgment as Burton did, for the evidence that the letter was either intended for or actually sent to Cheyne is not definitive. John P. Wright is Professor of Philosophy, Central Michigan University, Mt. Pleasant, MI 48859, USA. e-mail: [email protected] 126 John P. Wright Burton, who first published the autobiographical letter of the 22-yearold Hume in 1846, narrowed down the possible addressees of Hume's letter to either Cheyne or John Arbuthnot. He also pointed out that it is possible that the letter was never sent, and that the ten and a half page manuscript is only a neatly written draft, rather than a fair copy of an actual letter. Nevertheless, Burton thought he could identify the unnamed addressee on the basis of the internal evidence of the manuscript and the records of Scottish physicians practicing in England at the time. In the letter, Hume refers to the intended recipient as his "Countryman, a Scotchman [,]... a skilful Physician, a man of Letters, of Wit, of Good Sense, & of great Humanity."8 Further he writes that he is consulting him because he is a person "of great Learning beyond [his]... own Profession" who is acquainted with the "Motions of the Mind" he has described in his letter, and that "Fame pointed [him]... out as the properest person to resolve my Doubts..." about the cure of his disorder.9 Burton tells us that "the first name that suggested itself... was Arbuthnot, whose fine genius was just then flickering in the socket."10 (John Arbuthnot had been ill for some time, and died a year later.) But he then added that "a more full consideration showed to my satisfaction that it must have been destined for Dr. George Cheyne." His main reason for settling on Cheyne was that Cheyne's immensely popular The English Malady (1733) had recently been published, and that "there is a certain unison of tone between Hume's letter and this book." Burton quotes a portion of Cheyne's own long autobiographical account of his own disease in The English Malady. Cheyne's autobiography begins with the claim that "I passed my Youth in close study, and almost constant Application to the abstracted Sciences, (wherein my chief pleasure consisted) and consequently in great Temperance and a Sedentary Life"; it is followed by the reflection that any overindulgence in food or drink led to physical and psychological problems.11 He goes on to describe these in great detail for 39 pages, along with a history of his life. Burton also quotes a section of the book in which Cheyne describes how a studious and sedentary life causes the symptoms... (shrink)

A new axiomatization of set theory, to be called Bernays-Boolos set theory, is introduced. Its background logic is the plural logic of Boolos, and its only positive set-theoretic existence axiom is a reflection principle of Bernays. It is a very simple system of axioms sufficient to obtain the usual axioms of ZFC, plus some large cardinals, and to reduce every question of plural logic to a question of set theory.

One hundred years ago, in his lecture Science as a Vocation, Max Weber prefigured a transition from science as a calling to science as bureaucratically organized work. He argued that a calling for science is critical for sustaining scientific work. Using Weber’s arguments for science as a vocation as a lens, in this paper, we discuss whether a calling for science may become difficult to maintain in increasingly bureaucratized scientific work—and also whether such a calling is necessary for the advance (...) of science. We present empirical evidence for this bureaucratization of scientific work and further develop Weber’s discussion of science by contrasting it with the views of other theorists of science and innovation. Finally, we discuss the implications of these theories, develop a set of policy recommendations, and outline a research agenda designed to develop science policies and a sociology of science that match this shift from vocation to bureaucracy in scientific work. (shrink)

A comprehensive history of how induction has been conceived, from Socrates to Karl Popper.

In this paper I discuss whether Gödel's incompleteness theorems have any implications for studies in Artificial Life (AL). Since Gödel's incompleteness theorems have been used to argue against certain mechanistic theories of the mind, it seems natural to attempt to apply the theorems to certain strong mechanistic arguments postulated by some AL theorists. -/- We find that an argument using the incompleteness theorems can not be constructed that will block the hard AL claim, specifically in the field of robotics. However, (...) we will see that the beginnings of an argument casting doubt on our ability to create living systems entirely resident in a computer environment might be suggested by looking at the incompleteness theorems from the point of view of Gödel's belief in mathematical realism. (shrink)

Parsons has given a (nonconstructive) proof that the first-order fragment of the system of Frege's Grundgesetze is consistent. Here a constructive proof of the same result is presented.

It is correctly asserted that the intensity of the current debate over the use of animals in biomedical research is unprecedented. The extent of expressed animosity and distrust has stunned many researchers. In response, researchers have tended to take a strategic defensive posture, which involves the assertion of several abstract positions that serve to obstruct resolution of the debate. Those abstractions include the notions that the animal protection movement is trivial and purely anti-intellectual in scope, that all science is good (...) (and some especially so), and the belief that an ethical consensus can never really be reached between the parties. (shrink)

This paper is the second of a multi-part examination of the creation of the Babylonian mathematical lunar theories known as Systems A and B. Part I (Britton 2007) addressed the development of the empirical elements needed to separate the effects of lunar and solar anomaly on the intervals between syzygies. This was accomplished in the construction of the System A lunar theory by an unknown author, almost certainly in the city of Babylon and probably early in the 4th century B.C. (...) The present paper focuses mainly on System A and the likely process of its construction. The first three sections are largely descriptive – first of the basic concepts which underlie the theory; then of the component schemes comprising the theory; and finally of two distinctive texts which suggest how the theory was constructed. The crux of the paper is Sect. 4, which describes how the theory seems likely to have been constructed. Here the crucial insight in separating the effects of lunar and solar anomaly appears to have been recognizing that – of all the measurable intervals bounded by eclipses – only 235 months exhibits a variation due solely to lunar anomaly, and that by means of an elegant mathematical model the amplitudes of 223 and 12 months could be deduced from its amplitude. The rest of the section describes the likely details of the derivation of the Φ ~ Λ scheme, and the extension of the methodology to the other components of the theory. It concludes with a demonstration that Φ and its dependent schemes were anchored through the Φ ~ W scheme to the syzygy on –403 Aug 18 (GN 7391) which concluded the shortest 6-month interval in the first 24 saros cycles since –746 (and in fact in the 900 years separating Nabonassar and Ptolemy). The next three sections address a number of largely technical details and amplifications of the theory, beginning with the schemes describing the variation of lunar velocity (column F) in Sect. 5. Section 6 addresses issues concerning the interpretation of Φ and the so-call Saros Text (BM 36705), while Sect. 7 discusses System B’s corresponding treatment of the effects of lunar anomaly, illustrating both its derivative nature and mathematically less rigorous structure. Section 8 examines the accuracy of the two theories, showing that the System A theory was both remarkably accurate and superior to System B. The final section offers some brief remarks on the power and elegance of the mathematical treatment of the problem by the author of System A. (shrink)

This essay reevaluates the Weimar writings of Carl Schmitt and Leo Strauss, specifically, their intellectual efforts to replace the political authority of Kantian liberalism with, respectively, a ‘political theology’ and ‘Biblical atheism’ derived from the thought of early-modern state theorists like Hobbes and Spinoza. Schmitt and Strauss each insisted that post-Kantian Enlightenment rationality was unraveling into a way of thinking that violently rejected ‘form’ of any kind, fixated myopically on material things and lacked any conception of the external constraints that (...) invariably condition the possibilities of philosophy, morality and politics. They considered Kantian reason and liberal politics to pose serious threats to ‘genuine’ expressions of rationality and as dangerous obfuscations of the necessity of political order—of the brute fact that human beings stand in need of ‘being ruled,’ as such. (shrink)

This commentary challenges the conclusions reached by Franklin Miller and Robert Truog in their criticism of the President's Council's White Paper, "Controversies in the Determination of Death." I agree with much of Miller and Truog's criticism of the rationale offered by the President's Council for accepting neurological criteria for determining death but argue that they too quickly dismiss the alternative rationale of determining death by neurological criteria-i.e., the destruction of the psychophysical integrity of the human being that occurs when the (...) potential for consciousness and every other mental function is lost due to catastrophic injury to the brain. By focusing on the death of bodies instead of human beings, their view absurdly implies that decapitation would not necessarily result in one's death. Since total brain failure is a form of physiological decapitation, the neurological criterion coheres perfectly well with the ordinary understanding of decapitation as death. (shrink)